2/14/2023 0 Comments Sanchez one in a million rar![]() FOP is normally manifested at birth by a characteristic skeletal malformation in the great toe ( hallux valgus), and the disease progresses throughout the lifetime of the patient sequentially affecting muscle, ligaments, tendons and other connective tissues all over the body, following a predefined anatomical pattern. FOP affects one in two million individuals and is characterized by congenital skeletal abnormalities and postnatal progressive HO. In contrast to acquired HO, Fibrodysplasia ossificans progressiva (FOP MIM #135100) represents the most devastating hereditary disorder involving HO. The formation of new bones at extra skeletal sites, named heterotopic ossification (HO), is a common post-operative complication upon orthopedic surgeries (i.e., hip replacements), blast injuries, skeletal trauma and some nervous system disorders. Department of Molecular Cell Biology (Room R2-24), Leiden University Medical Center, Postzone S-1-P, P.O-Box 9600, 2300RC Leiden, The Netherlands.
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